[1] Beretta markets the Neos as a modern, reasonably priced pistol suitable for a beginner, yet is customizable to suit the experienced marksman.

[6] In addition to the United States and Canada,[7] the U22 Neos is listed for sale by Beretta distributors in Australia,[8] France[9][10] and some other European countries.

Beretta released the U22 Neos Carbine Kit (to convert the pistol into a long gun) in 2004.

[5] In September 2010 Beretta instituted a recall of some U22 Neos models because of the remote possibility that the pistol could fire with the safety on.

[17] Beretta USA announced in July, 2014 that firearms production in Accokeek, Maryland (where the Neos is manufactured) would be moved to Gallatin, Tennessee.

The pistol does not have a full-length slide (i.e., the barrel is uncovered) and it functions by cycling the rear portion of the action.

[19][better source needed] The U22 Neos is designed for field stripping without tools into basic modules (barrel with sight rail, receiver, slide and firing pin) for cleaning.

[19][better source needed] The magazine holds ten rounds, giving the Neos a total 10+1 capacity.

[6] The origin of the pistol's sleek shape and ergonomics was a collaboration between Beretta engineers and Giugiaro Design stylists.