Located in the eastern part of the county, it borders the following townships: Two villages are located in Berkshire Township: Galena in the south, and most of Sunbury in the east.

Berkshire Township was settled by Colonel Moses Byxbe in 1806 and named for Byxbe's former home of Berkshire County, Massachusetts.

[4] The township is governed by a three-member board of trustees, who are elected in November of odd-numbered years to a four-year term beginning on the following January 1.

There is also an elected township fiscal officer,[5] who serves a four-year term beginning on April 1 of the year after the election, which is held in November of the year before the presidential election.

Emergency medical services in Berkshire Township are provided by the Delaware County EMS.