The Berlin territorial reform, in effect from 1 April 1938, also affected the districts of Treptow and Köpenick.

In the Nazi era, Oberschöneweide developed into a stronghold of resistance against National Socialism, which despite constant arrests and death sentences could not be broken.

In the Allied air raids on 21 June and 6 August 1944, Oberschöneweide endured heavy carpet bombing, while the Kabelwerk Wilhelminenhof was heavily damaged.

[2] Due to changing economic trends since German reunification on 3 October 1990, many companies have suffered layoffs, closures, and privatisations.

Samsung gave up the location despite the receipt of millions in subsidies by the state of Berlin, due to sales problems and inefficiency.

The other bridge, Wilhelminenhofbrücke, whose construction project is still in planning, is to lead to the eastern extension of Wilheminenhofstraße over the Spree to Schnellerstraße in the Oberspree.

Located in the south-eastern side of the city and crossed by the river Spree, Oberschöneweide borders the localities of Plänterwald, Baumschulenweg, Niederschöneweide, Köpenick, Karlshorst and Rummelsburg (both in Lichtenberg district).

Its urban park is the Wuhlheide, site of the miniature railway Berliner Parkeisenbahn (BPE), used during the East German period by the Young Pioneer Organisation.

The Hochschule für Technik und Wirtschaft (HTW - translated as University of Applied Sciences for Engineering and Economics), the youngest and largest University of Applied Sciences in Berlin, is located on the Campus Wilhelminenhof [3] located in Oberschöneweide.

At Wilhelmstrand, by the river, there is a short ferry service (line F11) that links it to Baumschulenstraße, in Baumschulenweg.

There were plans for the U5 to be extended from Friedrichsfelde via Karlshorst to Oberschöneweide in the 1950s, however this was not realized with the extension to Hönow in the late 1980s.