The adjacent underground station is one of the largest on the Berlin U-Bahn network, with lines U2, U5, and U8 stopping there.

Alexanderplatz station opened on 7 February 1882 on the Berlin Stadtbahn viaduct from Charlottenburg to Ostbahnhof (then named Schlesischer Bahnhof).

Heavily damaged in World War II, train service at the station resumed on 4 November 1945, while the reconstruction of the hall continued until 1951.

The platforms of lines U8 and U5 opened on 18 April 1930 and 21 December 1930 respectively, also built according to Grenander's conception, but in a distinct Modern style.

The U5 station was renovated between February 2003 and September 2004; it was the western terminus of the line from 1930 to December 2020, when it was extended to Berlin Hauptbahnhof.