On November 17, 2016, Epix renewed Berlin Station for a second season, originally planned to contain ten episodes, which premiered on October 15, 2017 and concluded a nine-episode-season-run on December 3, 2017.

In season 1, Miller has a clandestine mission: to uncover the source of a leak who has supplied information to a now-famous whistleblower named Thomas Shaw.

Guided by veteran Hector DeJean (Rhys Ifans), Daniel learns to contend with the rough-and-tumble world of the field agent: agent-running, deception, and the dangers and moral compromises.

The whole interior of the CIA Station, which includes a security entrance as well as the big windowless office space within, was built on stages at Babelsberg's studios.

[21] In a season 1 review for Variety, Maureen Ryan attests the series "an outstanding cast that takes its reasonably solid storytelling and raises it a few notches through sheer talent and charisma", praising especially Richard Jenkins, Michelle Forbes and Rhys Ifans.

[22] The New York Times' Mike Hale called season 3 a "well-made but not hugely original mix of spycraft, action and sexy office intrigue" and noticed that "Berlin Station is elevated by the surprising, and relatively unnoticed, quality of its core cast", mentioning particularly Leland Orser whose "shifty, nervous energy still carries the show".