"[4] Off-Broadway she originated the roles of Jane in Linda Faigao-Hall's Dying in Boulder at La Mama[5] and Aviva in Staci Swedeen's The Goldman Project (Abingdon Theatre).

"[7] Quigley’s range of roles in regional theaters include Lady Bird Johnson in Robert Schenkkan’s All the Way, Agnes in Tracy Letts’ Bug (Repertory Theatre of St. Louis), the title role in Martin McDonagh's The Beauty Queen of Leenane (opposite Eileen Brennan at Virginia Stage), and Elizabeth Proctor in Arthur Miller's The Crucible (Repertory Theatre of St. Louis and Cincinnati Playhouse).

[8] Quigley has also played supporting characters in feature films such as The Garden Left Behind directed by Flavio Alves,[9] Olivia Peace's Tahara, Heidi Philipsen & Jon Russell Cring's Darcy, Stuart Connelly's The Suspect, and Jim Sheridan's Oscar-nominated In America.

[10] Publishers Weekly wrote: "Quigley scrupulously brings Fielding's vapid, iconic characters to life with her uncanny ability to switch between accents and mood at the drop of a hat, achieving a subtler style of comedy than listeners may expect.

After her mother's death at 99 years of age, in an article for Boston.com, Bernadette "recalled being struck by her parents’ convictions and the lessons they taught their children — to stand up against “racism and hypocrisy.”".