Her work has been compared to other artists of her generation such as Thomas Hart Benton, Grant Wood, and Norman Rockwell.
The couple spent a year abroad, studying art in London and Paris before returning to settle in New York City in 1930.
[3] Custer divided her time teaching at the Pratt Institute, creating her own artwork, and producing commercial and editorial art for a number of magazines such as The New Yorker, Pageant, Seventeen, New Republic, Fiction Parade, and Survey Geographic.
[11] Two of Custer's watercolors were among the federally sponsored artworks that were allocated to the T. W. Wood Gallery in Montpelier, Vermont, and they remain in this museum's permanent collection.
Custer's preferred medium was a combination of pen-and-ink with watercolor, which allowed her to add a sense of frantic energy to her work.
The Londonderry Historical Society now runs the Bernadine Custer Sharp House as a temporary gallery space during the summer months.