Guignedoux made his debut for PSG in the first game of the club's history on 23 August 1970, a 1–1 league draw against Poitiers.

He scored the first goal in PSG history as he found the top-left corner from a shot on a free-kick.

[6] In an interview with PSG70 in 2005, Guignedoux recalled his favorite memory from his time as a PSG player being the promotion to the Division 1 in 1971.

He returned to the PSG C team in February 2002, only to go back to his position in the youth academy five months later.

[citation needed] Twelve months later, he stepped down from the position to become a scout for the club's youth academy.

In June 2005, Guignedoux joined Valenciennes as the assistant manager of the club, once again in a collaboration with Kombouaré.

Valenciennes won the Ligue 2 and achieved promotion in Guignedoux's first season as assistant coach.