A renowned virtuoso keyboard player, he was one of the most important Italian composers for harpsichord between Girolamo Frescobaldi and Domenico Scarlatti, having also made substantial contributions to opera and oratorio.
[3] As a composer and keyboard player, Pasquini collaborated on music performances for a host of famous patrons in Rome, such as cardinals Flavio Chigi, Benedetto Pamphili, and the politically savvy Pietro Ottoboni.
"[7] He composed numerous operas, all staged in Rome between 1672 and 1692, and which were performed again or excerpted in shows at several Italian theatres (Florence, Pisa, Naples, Ferrara, Perugia, Genoa, Rimini etc.).
Many important musicians of the late 1600s and early 1700s had lessons from him including Georg Muffat, who praised Pasquini for having taught him "the Italian way of playing the organ and harpsichord.
[citation needed] Pasquini died in Rome on 21 November 1710, and was buried in his parish church of San Lorenzo in Lucina.