[2][3] Already at the age of 18, midfielder Brexendorf was a member of the SV Werder Bremen Bundesliga squad.
In the home match versus Borussia Mönchengladbach he came in as a substitute with ten minutes to go, Bremen holding a 2–2 draw.
He could, however, not prevent Werder losing the match by a Jupp Heynckes goal scored three minutes before the final whistle.
In his second Bundesliga season he suffered a similar fate; he appeared in five matches, only one of which – away at Bochum – saw him play full-time.
For the 2007–08 season, FC Schalke 04 hired Brexendorf as successor of Thorsten Rarreck, who had been club doctor for nine years.