Bernie is a city in southern Stoddard County, Missouri, United States.

The St. Francis River is about ten miles to the west on Missouri Route U.

[7] According to the United States Census Bureau, the city has a total area of 1.31 square miles (3.39 km2), all land.

There were 916 housing units at an average density of 699.2 per square mile (270.0/km2).

29.1% of all households were made up of individuals, and 14.7% had someone living alone who was 65 years of age or older.