It is one of the highest ranges of the Alps, covered with many glaciers.

The peak in the range which sees the most ascents is Piz Palü.

The Bernina Range is separated from the Albula Range in the north-west by the Maloja Pass and the Upper Engadin valley; from the Livigno Range in the east by the Bernina Pass; from the Bergamo Alps in the south by the Adda valley (Valtellina); and from the Bregaglia Range in the south-west by the Muretto Pass.

The Bernina Range is drained by the rivers Adda, Inn and Maira (Mera in Italy).

The term Bernina Alps can also be used in an extended sense to include both the Bernina and Bregaglia ranges; this is the area coloured red on the map (right) and labelled 'Bernina Alpen'.