[3][4] He wrote twenty books, including Eleven Blue Men (1954), The Incurable Wound (1958), Feral (1974), and The Medical Detectives (1980).

[3] An article he wrote for The New Yorker was made into the 1956 film Bigger Than Life,[3][5] and many of the medical mysteries on the television show House were inspired by Roueché's writings.

An article he wrote for The New Yorker, entitled "Ten Feet Tall", was made into a 1956 film called Bigger Than Life, which stars James Mason.

[3][13] Roueché remained a staff writer for The New Yorker until his death, a span of about fifty years.

[3] Roueché's writings, especially his book The Medical Detectives (1980), inspired in part the television show House, which premiered in 2004 on the Fox network.

[6][7] His 1954 book Eleven Blue Men, which was a collection of pieces he had written for The New Yorker, was awarded a Raven by the Mystery Writers of America.