Besse-et-Saint-Anastaise (French pronunciation: [bɛs e sɛ̃.t‿anastɛz]; Occitan: Bèssa), also known as Besse-en-Chandesse (its official name from April 2, 1961, to July 1, 1973), or Besse (its name before 1961), is a commune in the Puy-de-Dôme department in Auvergne-Rhône-Alpes in central France.

The nearby ski resort of Super-Besse hosted the first mountain finish of the 2008 Tour de France.

The river Rhue has its source in the commune.

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