In 2006, BestWeekEver.tv was launched to serve as more of a daily blog mostly separate from the program itself (beyond promotions and tie-ins for the show), detailing humorous stories in the news, odd television and YouTube videos, and features main contributors Alex Blagg, Bob Castrone, Michelle Collins, Dan Hopper, and formerly Sara Schaefer's observations on pop culture and other items.

Beginning October 24, 2008, the show adopted a format with a single host who summarized the week's events.

Tompkins occasionally threw to panelists (usually Jessica St. Clair, Paul Scheer, Mike Britt, or Doug Benson) who offered their own take on a particular subject.

Next was "In Case You Missed" which briefly showcases several short clips from the week's television (and occasionally the Internet and radio).

Recipients include Barack Obama (after beating out Hillary Clinton for the 2008 Democratic Presidential nomination), the Dramatic Prairie Dog, 2 Girls 1 Cup, and Midget Mac.

New York magazine reported that Best Week Ever was on an extended hiatus until January 2010 and that it would return in the fall with Paul F. Tompkins hosting.

In a 2005 interview on The Daily Show with Jon Stewart, NBC Nightly News anchor Brian Williams said: "We have such short attention spans.

[10] In an article on the Pipe Dream website about VH1's decade-retrospective shows, writer Jeanette Duffy noted that "VH1 has moved on from exploiting entire decades to making us reminisce over events that happened just days ago in the Best Week Ever", jokingly suggesting that cable networks might eventually produce the "Best Five Minutes Ever".