Best of Chris Isaak is a greatest hits album by Chris Isaak released on May 9, 2006 on the Reprise/Warner Bros. Records label.

The 18 song collection has three new tracks: "King Without a Castle", "Let's Have a Party" and a cover of Cheap Trick's "I Want You to Want Me".

Note: the "Solitary Man" video (not listed on the CD cover) is only available with the audio commentary on.

All songs written by Chris Isaak and published by C. Isaak Music Publishing Co. (ASCAP) except: All songs mastered by Steve Hall at Future Disc.

* Sales figures based on certification alone.^ Shipments figures based on certification alone.