In 2022, she portrayed country singer Gigi Roman on the Fox drama series Monarch, and two years later, Gossip reformed.

In 2011, she released her own 4-track Beth Ditto EP, produced by James Ford and Jas Shaw of Simian Mobile Disco, on the re-launched Deconstruction Records.

Harrod Horatia, writing in The Telegraph, has said, "Where the stripped-down three-piece Gossip play propulsive, garage band blues, Ditto's own stuff is melancholic, soulful dance music, inspired by 'Eighties disco soul jams' that she loves, and the up-tempo pop-R&B of I Wanna Dance With Somebody-era Whitney Houston.

[16] She also stated: "Artists I love, like Siouxsie Sioux and Patti Smith, have such radically different ways of embodying femininity, but they're both amazing punk women.

[1] Germaine Greer, writing in The Guardian, said the magazine had "enough courage to put the coolest woman on the planet on the cover" whilst acknowledging its limits.

Greer also praised Ditto for her motives, saying her "intention is to force acceptance of her body type, 5 ft [1.5 m] tall and 15 stone [210 lb; 95 kg], and by this strategy to challenge the conventional imagery of women".

[21] In February 2009 bi-annual British style magazine Love featured Ditto posed nude on the front cover of its premiere issue, with prominent public advertising.

[22] Ditto launched her first plus-size collection for women's clothing retailer Evans on July 9, 2009, in collaboration with head of design Lisa Marie Peacock.

Ditto provided sketches and drew inspiration from her favourite vintage and charity shop clothes as well as bands like Blondie, The Slits and Grace Jones, and Art Deco movements.

[36] Earlier that month, she addressed how her relationship with Kwo, who is an openly transgender man, has urged her to consider the privileges of being perceived as a straight woman.