Bethesda is an unincorporated community in southeastern Durham County, North Carolina, United States, on South Miami Boulevard, off U.S. Route 70.

The community has two churches, two schools, and a ZIP code of 27703.

It has mostly been annexed into the city of Durham.

Bethesda was named for Bethesda Baptist Church, which was organized in 1884.

This article about a location in Durham County, North Carolina is a stub.