She previously served as the Member of Parliament representing Lubaga North Constituency on the Forum for Democratic Change (FDC) ticket from 2006 until 2010.

[9][10] Kamya joined the National Resistance Movement party[11] and in 2020 she participated in the flag bearer elections for Lubaga North constituency as a candidate.

[12] She won Brian Tindyebwa and Dr. Isaac Lwanga to become the official NRM flag bearer in the 2021 presidential and parliamentary elections.

[22] In the mid 1980s, she joined Uganda Leather and Tanning Industries Limited in Jinja in the sales department, working there until 1988.

From 1999 until 2004, she was the executive director of the Uganda Wildlife Education Centre (UWEC) in Entebbe, about 36 kilometres (22 mi), by road, south of Kampala on the northern shores of Lake Victoria.

[24] In a cabinet reshuffle on 14 December 2019, she was named the Minister of Lands, Housing and Urban Development, switching dockets with Betty Amongi, who took over at Kampala Capital City Authority.