She is known for playing Marie Schrader on the AMC crime drama series Breaking Bad (2008–2013) and Heather Hughes on the CBS sitcom Life in Pieces (2015–2019).

After winning the lead in a high school production of Exit the Body, she shifted her focus to acting.

[7] After graduation, Brandt moved to Seattle, Washington, where she worked in theater while appearing in several short films, beginning with Confidence in 1998.

In theater, Brandt has acted in performances of Much Ado About Nothing with the Arizona Theatre Company, with the San Jose Repertory Theatre, Beth Henley's Ridiculous Fraud, Julia Cho's The Language Archive with South Coast Repertory, and Next Fall with Geffen Playhouse.

She has had guest roles on the television shows Without a Trace, Judging Amy, ER, Boston Legal, The Practice, and NCIS.

[citation needed] On June 6, 2010, Brandt was honored as the 2010 Distinguished Alumnus at the Bay City Western High School commencement, and was a featured speaker.