Betsy Layne is a census-designated place (CDP) and coal town in Floyd County, Kentucky, United States.

[4] Stage actress Bette Henritze (born 1924) was a native of Betsy Layne.

Betsy Layne is located along the eastern border of Floyd County.

In addition to being treated as a census-designated place by the United States Census Bureau, they also consider Betsy Layne and the nearby community of Stanville as a combined Census County Division (CCD).

The CCD also includes the communities of Banner, Dana, Harold, Ivel and Tram.