She served in the 45th Senate District, which includes all or part of Clinton, Essex, Franklin, Hamilton, Warren and Washington Counties.

[10] Despite the district being competitive on paper, Little easily won election to her first term in the Senate against Democrat Boyce Sherwin, 77% to 23%.

[13] After the appointment of Kirsten Gillibrand to the United States Senate in January 2009, Little expressed interest in running for U.S. Congress in New York's 20th congressional district and announced her intention to seek the Republican nomination for the special election for the seat.

[15] Before the Republicans lost the Senate majority in the 2018 elections, Little served as Chair of the Housing, Construction and Community Development Committee.

[17] Little has said she believes universal health care should be passed at the federal level to avoid unduly burdening the state.