Nguyen began her career as a morning anchor and reporter at KWTX-TV, the CBS affiliate in Waco, Texas.

[2] Then, she was an anchor at KTVT-TV, the CBS affiliate in Fort Worth, where she covered numerous breaking news events, including the Columbia disaster.

She spent six years at CNN covering major news events including the 2010 Haiti earthquake, presidential elections in Africa, Hurricane Katrina, and the death of Pope John Paul II.

[2][3] During her tenure, she was also a substitute anchor on the weekend edition of the CBS Evening News and a Special Correspondent for Entertainment Tonight.

[5] Nguyen was recognized by the Smithsonian Institution in 2007 as the first Vietnamese-American to anchor a national television news broadcast in the United States.

Nguyen became the new co-anchor of the PIX11 Morning News at WPIX-TV on June 19, 2017, succeeding Sukanya Krishnan, who left the station after 17 years.

Nguyen will join co-anchor Keith Jones, meteorologist Lissette Gonzalez and breaking news and traffic anchor Austin Carter from 4:30 a.m. to 7 a.m. starting March 13.

She was a cheerleader during her younger days and a member of the Zeta Tau Alpha sorority in college.