This fact is the origin of the band's name, which is an ad lib translation of the Hebrew term "Beit Sefer", meaning "school".

The original lineup included singer Avital Tamir, guitarist Matan Cohen, drummer Roey Berman and bassist Menashe "Mashy" Hazan.

Following the usual gigs as a cover band and several replacements of the bass players, Betzefer started their own songwriting.

In June 2004 the band took off to Belgium to record their first full-length album, Down Low, with producer Kris Belaen to whom they were introduced by Sven De Caluwe of Aborted and Whorecore.

They eventually recorded the album with Belaen, while the final mixing and mastering was done by Danish producer Tue Madsen.

They then performed at the Hellelujah Open Air, a donation heavy metal festival in Herzliya, Israel, on 30 May 2008, in which they said they were recording the crowd for a new song called "Doomsday" in which vocalist Tamir stated they needed to have people shouting gang vocals of the word "Day" in the chorus, for the record.

Alongside the band played such acts as Sabaton, Tim "Ripper" Owens, Nightmare and Almana Shchora.

On 28 September 2010, the band performed as part of Ozzfest, taking place in Israel for the first time, alongside Ozzy Osbourne, Korn, Soulfly and Almana Shchora.

[7] On 20 January 2011, the band released the song "Nothing But Opinions", the first single from the upcoming album, for free listening through such Israeli sites as Walla!,[8] Nana 10[9] and Musicspot.

[13][14] On 11 August 2012, the band announced on their official Facebook page that they have finished recording their third album, which will contain 13 tracks and will be called Suicide Hotline.

On 13 April 2013, the band shot a music video for their upcoming new single "Sledgehammer" at the Galit skate part in Tel Aviv, inviting fans to participate in the shooting.

[18][19] On 31 August 2013, the band unveiled the cover art for their upcoming album The Devil Went Down to the Holy Land, announcing it will be released on 28 October 2013.

[23] On 15 June 2016, he uploaded a photo of him and bassist Rotem Inbar tracking bass for the album, to his Facebook page.

It was also announced that replacing Tamir would be Shredhead vocalist Aharon Ragoza, who would be recording the new album with the band, and performing his first show with them on 17 August 2016, at the Barby club in Tel Aviv.

In another interview with Avital Tamir and Matan Cohen, they stated AC/DC, Aerosmith and Black Sabbath as their rock-rooted influences.