[2] While in a hotel with too much drink, drugs and time, the cast and crew of a film are gradually unravelling as they await the arrival of their director.

Beware of a Holy Whore opens with a soliloquy (delivered by Werner Schroeter) about the synopsis of a Disney story featuring Goofy, the dog.

When Willy's true identity is revealed the confused Goofy says, "What a shock that must have been for the poor little girl when she discovered that she is a crook".

This opening soliloquy alludes to the film's underlying themes of violence, self-blindness, and same-sex and bisexual relationships.

[3] The action of the movie then moves to a coastal hotel in Spain where the cast of the film's meta-film "Patria O Muerte" are waiting for production money and the director (Lou Castel) and the star (Eddie Constantine, as himself) to arrive.