The Beyonders were first mentioned in the team-up comic Marvel Two-in-One #63 (May 1980), by Mark Gruenwald and Jerry Bingham.

[4] For millennia they were not observed by any being of the Earth dimension (apparently including even the near-omniscient Watchers themselves); their 'true form' is unknown because each mind that views them struggles as best as it can to perceive an unknowable force as an image it can comprehend.

In fact, their nature is so alien that they are constrained and restricted to their own sequential timeline which prevented them from leaving their dimension or travel through time.

They first came to the attention of Earthlings when they commissioned the alien Nuwali race to create the Savage Land as part of their study of evolution.

[5] They eventually hired the Pegasusian alien race as agents, to tow Counter-Earth to the Beyonders' museum.

When the Evolutionary arrived at the Beyonders' planet museum, he himself reported that his mind snapped when he witnessed the scope of their powers and how effectively insignificant he was compared to these alien beings.

[6] Every now and then the Beyonders would shunt a modicum of energy to the universe, allowing sentient beings to use them to create Cosmic Cubes—a practice they appear to have given up after the admonishments by Eternity and the Living Tribunal regarding the disruptive effect of these actions.

[9] Upon returning to Earth, he tells his fellow heroes that the Beyonders have killed the Living Tribunal along with all the Celestials, and every abstract entity (including Eternity, Infinity, Lord Chaos, Master Order, and the In-Betweener) as part of an experiment involving the destruction of all life throughout the Marvel Multiverse.

[10] Later, Rabum Alal reveals to Doctor Strange that the Beyonders are responsible for the accident that turned Owen Reece into the Molecule Man, by using the child unit "The Beyonder" which in turn made the Molecule Man to be a singularity—identical in every reality—to function as a "bomb" that would destroy its native universe.

[11] It was soon revealed that Doom's attack was a bomb made of Molecule Men he collected from throughout the Multiverse, which not only allowed him to destroy the Beyonders but at the same time channel the resulting energy into Owen Reece, and use that energy to collect what remained of the Multiverse into a single planet known as Battleworld.

[12] A number of survivors of the Multiverse were also collected and brought to Battleworld, now under the reign of the now-cosmically powered "God Emperor" Doom - their memories altered to become the lords and ladies of various factions of a medieval new order.