The Bezirksliga Main-Hessen was the highest association football league in the German state of Hesse and the Prussian province of Hesse-Nassau from 1927 to 1933.

In the 1931-32 season, both divisions expanded in strength, Main to eleven and Hessen to ten teams.

With the rise of the Nazis to power, the Gauligas were introduced as the highest football leagues in Germany.

In the region, the Gauliga Südwest/Mainhessen replaced the Bezirksliga Main-Hessen as the highest level of play.

The clubs from the Hanau and Friedberg region however were added to the new Gauliga Hessen.