Bianca Hunter's first appearance was an uncredited role at the age of 3 in a scene with Al Pacino in Serpico (1973), directed by Sidney Lumet.

[2] In 1986 she appeared in the music video "Papa Don't Preach" by Madonna with Danny Aiello and Debi Mazar.

At 18, Hunter played Karen Hill's (Lorraine Bracco) best friend in the wedding scene in Goodfellas (1990).

After seeing her harrowing portrayal of a teen being sexually harassed by Harvey Keitel in Abel Ferrara's Bad Lieutenant (1992), Steve Buscemi cast her in his directorial debut Trees Lounge (1996).

She has appeared in a dozen films including the David O. Russell-directed biographical film The Fighter (2010), nominated for seven Academy Awards and winning the awards for Best Supporting Actor (Christian Bale) and Best Supporting Actress (Melissa Leo).