During the Bishop's conflicts with the Holy Roman Empire over the Lombardy provinces, Biasca and the surrounding region suffered from armies marching through the valley.

[3] A branch of the Orelli family of Locarno was given the castle above Biasca, near the chapel of S. Petronilla, in the 12th century.

However, in 1292 the village was able to push through an agreement that allowed them to elect some local leaders, giving them limited self-government.

The Orelli family ruled until the middle of the 14th century, when their territory was incorporated into the dominion of the Visconti.

In 1403, after the death of Gian Galeazzo, the Visconti Duke, Biasca was conquered by the two Swiss cantons of Uri and Obwalden and incorporated into the Italian bailiwicks of the two towns.

The Duke of Milan reinforced Biasca and in 1441 made it a bulwark against the Leventina valley which had been conquered by Uri.

The town reached an agreement in 1450 with the new Duke of Milan, Francesco Sforza, which confirmed the previously extended rights.

[3] In 1512, a landslide from Monte Crenone created a dam across the Brenno river north of the village.

Due to its location on a major Alpine road traffic, the local economy gradually recovered from this disaster.

However, at the end of the 16th and at the beginning of the 17th century, at least three major plague epidemics hit the town.

After repeated searches, Charles Borromeo chose Biasca as the center to spread the reforms of the Council of Trent to the Tre Valli region.

[3] Located at the entrance to the Alpine valleys, Biasca as has always played an important role in regional and trans-Alpine trade, even after the Gotthard route opened in the early 13th century.

In the following years, the existence of a Sust or transshipment warehouse for the transit of goods is mentioned in Biasca.

Also, the granite mining industry is important to the whole region, and it reached its peak in Biasca in 1900.

In the wake of industrialization, the first economic class battles in Ticino broke out in Biasca.

The services sector has grown as Biasca has become a hub for the entire Tre Valli region.

The addition of Biasca on the trans-alpine rail link (NEAT) is expected to encourage it to continue its growth.

[3] The parish church of San Pietro dates back to the migration period following the collapse of the Western Roman Empire.

However, it appears that the Church of San Martino in Olivone formed another independent parish, at least until the mid-12th century.

The Church of SS Giacomo e Filippo was finished in 1468 the village, but was destroyed, along with other religious and secular buildings, during the wars of the early 16th century.

[3] A Catholic church, the Rotonda di San Carlo, is a magnificent example of the modern architecture of the Milanese architect Macciacchini.

About 3 km (1.9 mi) east of Biasca is the small lake of Carigiolo, from which a stream with an 80 m (260 ft) waterfall flows.

The villages of Loderio, Ponte, Pontirone, Sant'Anna, and Valle belong to the municipality.

[7] The age distribution, as of 2009[update], in Biasca is; 554 children or 9.3% of the population are between 0 and 9 years old and 615 teenagers or 10.3% are between 10 and 19.

Pietro e Paolo are listed as Swiss heritage site of national significance.

The town of Biasca and the village of Pontirone are both part of the Inventory of Swiss Heritage Sites.

[14] In the 2007[update] Gran Consiglio election, there were a total of 3,093 registered voters in Biasca, of which 2,029 or 65.6% voted.

In the tertiary sector; 432 or 32.2% were in wholesale or retail sales or the repair of motor vehicles, 75 or 5.6% were in the movement and storage of goods, 113 or 8.4% were in a hotel or restaurant, 1 or 0.1% were in the information industry, 58 or 4.3% were the insurance or financial industry, 93 or 6.9% were technical professionals or scientists, 143 or 10.6% were in education and 205 or 15.3% were in health care.

The wettest month is May during which time Biasca receives an average of 181 mm (7.1 in) of rain or snow.

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