Big Branch is an unincorporated community in St. Tammany Parish, Louisiana, United States.

The community is located on U. S. Route 190 5 mi (8.0 km) southeast of Mandeville and 3.5 miles northwest of Lacombe.

[2] The Big Branch Marsh National Wildlife Refuge lies along the coast of Lake Pontchartrain south of the community between Mandeville and Slidell.

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