"Big Eye" Louis Nelson Delisle (January 28, 1885 – August 20, 1949)[1] was an American Dixieland jazz clarinetist in New Orleans, Louisiana.

Nelson Delisle was born into a Creole of color family and spent most of his life in New Orleans.

By the age of 15, Delisle worked professionally in the music venues of Storyville, an area of brothels and clubs in New Orleans.

Early in his career Delisle often played a C clarinet, as opposed to the more common B♭; the C was used by other New Orleans clarinetists of the era, such as Alcide Nunez.

In 1917, Delisle joined the reconstituted Original Creole Orchestra that included Freddie Keppard and Bill Johnson.