Big Isaac is an unincorporated community in Doddridge County, West Virginia, United States.

Big Isaac is 6 miles (9.7 km) south-southeast of Salem, along Laurel Run, a headwaters tributary of Meathouse Fork.

[2] The Big Isaac post office[3] closed on December 31, 1962.

[4] According to tradition, the community bears the name of Periue "Big" Isaac, an early settler noted for his especially large shoe size.

This article about a location in Doddridge County, West Virginia is a stub.