Nate hates social studies teacher Mrs. Godfrey, whom he considers his nemesis, and calls her names like “the school's Godzilla”, usually centered around her weight.

He has a love-hate relationship with Artur, a foreign exchange student who is the boyfriend of Jenny, Nate’s crush, which is why.

Nate also loathes Gina, a “teacher’s pet” who gets good grades and is constantly acting like a suck-up to Mrs. Godfrey.

Peirce occasionally focuses on Nate's home life with his single father, Martin, and girly sister Ellen.

"I intended to feature a lot of stories about Nate's single dad, and all the comic possibilities inherent in that.

The images are never shown, but there were a few appearances of the eponymous character, as a life-size cardboard cut-out in a 2002 comic and as a cosplay actor visiting Klassic Komix in 2004.

The school is noted to be over 100 years old and is considerably run down, but was remodeled in Big Nate: Lives It Up after a painting by local folk artist Granny Peppers was found to be worth a lot of money.

Jefferson lost the Snowdown, because they took an uncreative approach by packing snow around the spare knight statue.

[3][4] In May 2013, a stage musical adaptation of the comic strip debuted at the Adventure Theatre MTC in Maryland.

[6][7][8] On February 19, 2020, it was announced that Big Nate would receive a 26-episode animated TV adaptation, which was slated to air on Nickelodeon in September 2021 but was delayed to 2022.