Big Run is an unincorporated community in Athens County, in the U.S. state of Ohio.
[1] A post office called Big Run was established in 1856, and remained in operation until 1907.
[2] The community took its name from nearby Big Run creek.
Besides the post office, Big Run had a railroad station (on the Marietta and Cincinnati Railroad) and a country store.
This Athens County, Ohio state location article is a stub.