Big Satilla Creek is a 55.8-mile-long (89.8 km)[1] tributary of the Little Satilla River in the U.S. state of Georgia.

It is part of the Satilla River watershed of southeastern Georgia.

The creek rises in Hazlehurst in Jeff Davis County and flows south, then southeast.

It joins Little Satilla Creek southwest of Screven to form the Little Satilla River.

This article related to a river in the US state of Georgia is a stub.