Big Sister was a daytime radio drama series created by Lillian Lauferty and broadcast on CBS from September 14, 1936, to December 26, 1952.

Set in the fictional town of Glen Falls, the program dramatized the life of Ruth Evans who sacrificed her own happiness to care for her younger sister Sue and their crippled brother Neddie.

[4] Over the years the program's writers, in addition to Lauferty, were Julian Funt, Carl Bixby, Bob Newman and Bill Sweets.

[5] In an indication of the program's popularity, listeners sent truckloads of wedding presents to the CBS studio when characters Ruth Evans and Dr. John Wayne were married.

To attract audience to the new show, Alice Frost reprised her role as Ruth Evans Wayne in early episodes of Bright Horizon.