The Bilaspur–Nagpur section is part of the Howrah–Nagpur–Mumbai line and connects Bilaspur in the Indian state of Chhattisgarh and Nagpur in Maharashtra.

Part of one of the major trunk lines in the country, it passes through a forested plateau region interspersed with fertile valleys.

By May 1854, Great Indian Peninsula Railway's Bombay–Thane line was extended to Kalyan.

Bhusawal station was set up in 1860 and in 1867 the GIPR branch line was extended to Nagpur.

[3] The Bengal Nagpur Railway was formed in 1887 for the purpose of upgrading the Nagpur Chhattisgarh Railway and then extending it via Bilaspur to Asansol, in order to develop a shorter Howrah–Mumbai route than the one via Allahabad.

[7] Work for conversion to 5 ft 6 in (1,676 mm) broad gauge of the 240 km (149 mi) narrow-gauge Gondia–Chanda Fort line started in December 1992, Gondia–Wadsa section was inaugurated on 25 September 1994.

[15] Bilaspur, Raipur, Durg and Nagpur on this line are amongst the top hundred booking stations of Indian Railway.