He attended Murray State College in Tishomingo, before transferring to East Central University in Ada, where he earned a bachelor's degree in accounting.

[1] In July 1975, Anoatubby was hired by the Chickasaw Nation government, then based in Sulphur, Oklahoma, to serve as Director of Tribal Health Services.

Anoatubby has devised a multi-pronged approach to improving conditions for the tribe in the areas of tribal finance, education, business and economic development, environmental protection, and healthcare.

[12] He has achieved the following: Anoatubby decided to run for national office in the 1998 election, he sought the Democratic Party nomination for the 3rd District U.S. House seat.

But Roberts was defeated by the Republican incumbent, Wes Watkins, who won re-election at a time of shifting political alliances by people in the state.

[17] Despite being a Democrat, Anoatubby endorsed conservative Republican and fellow Chickasaw T. W. Shannon in the 2022 United States Senate special election in Oklahoma.

[18] In addition to serving as governor, Anoatubby has been a member of numerous civic and governmental organizations at the local, state, regional and national levels.

Awards and honors include: Anoatubby lives in Ada, Oklahoma with his wife, the former Janice Marie Loman, who he married in December 1967.