[1] Block began his career as a literary agent before founding the Intertalent Agency in 1988, where he represented artists such as Kim Basinger, Samuel L. Jackson, Steven Seagal, Charlie Sheen, John Travolta, Forest Whitaker, Sam Raimi, Roland Emmerich and William Friedkin.
[2] Block founded Artisan Entertainment, an independent film studio that produced films including The Blair Witch Project; The Buena Vista Social Club; Darren Aronofsky's Pi and Requiem for a Dream; The Limey directed by Steven Soderbergh; The Ninth Gate starring Johnny Depp and directed by Roman Polanski; and David Koepp's Stir of Echoes and Made starring Jon Favreau and Vince Vaughn.
He was CEO of QED for 12 years, producing films including Neill Blomkamp's District 9 and Elysium, Oliver Stone's W. and David Ayer's WWII thriller Fury starring Brad Pitt.
In November 2015, he settled a legal dispute with QED, after his former company filed a federal lawsuit alleging trademark infringement and unfair competition concerning the rights to Dirty Grandpa.
[10] Block lives in the Hollywood Hills with his wife, Eugenia Kuzmina, a model, actress and comedian, his two sons and a daughter.