Bill Mathis (December 10, 1938 – October 20, 2020) was an American professional football player who was a running back for the New York Titans/Jets in the American Football League (AFL).

He also competed on the Clemson Tigers track and field team.

One of four Titans who remained with the New York Jets to play in and win a Super Bowl, Mathis led the AFL in carries in 1961 and was selected by his peers to the Sporting News 1961 AFL All-League team.

Mathis had a collarbone broken in the third game of 1961, against the Boston Patriots.

After retiring from football, Mathis began a career on Wall Street, starting at the firm Cogan, Berlind, Weill & Levitt.