He played Major League Baseball from 1930 to 1934 for the Chicago Cubs, Boston Braves, Washington Senators, and St. Louis Browns.

At the time of the 1910 United States Census, he was living in Smithville with his father William Fort McAfee, Sr. and two older sisters, Hilda and Mary.

[3][4] In September 1929, he traveled to Japan with the Michigan baseball team for a month at the invitation of Meiji University.

[9] The tall right-handed pitcher began his Major League Baseball career with the Chicago Cubs.

In one inning of work for the Cubs, he faced 10 batters and allowed three hits, two bases on balls, one wild pitch, and five unearned runs.

[12] In April 1930, The Sporting News reported on the expectations for McAfee: "McAfee did not show much promise in the conditioning search at St. Pete, but before the team left he was going along on high, [Bill] McKechnie spoke glowingly of his fast ball, curve, control and his pitching sagacity.

[10] McAfee spent most of the 1932 season as the property of the Boston Braves, but playing under option with the Montreal Royals in the International League.

[10] During the 1933 season, Washington Senators manager Joe Cronin used McAfee to replace Firpo Marberry "as chief of the relief pitching brigade.

[10] This season was also notable in that McAfee set a current mark for the lowest single-season strikeout rate among qualified major-league relievers ever, at 3.8%.

[19] In February 1935, McAfee announced that he was retiring from baseball to pursue a business career in Chicago with his father.

[22] McAfee was active in securing funding to construct the Southwest Georgia Regional Airport terminal which was posthumously named in his honor in 1959.

He was traveling with friends, including the president of the Citizens' and Southern Bank of Albany, in a twin-engined plane to the 1958 Major League Baseball All-Star Game in Baltimore.