He unsuccessfully sought the Democratic gubernatorial nomination in 1966 and election as Laramie County Clerk in 1970.

During World War II he served as a gunner aboard a destroyer, the USS Schroeder (DD-501), a Fletcher-class destroyer, this was a ship of the United States Navy, named for Rear Admiral Seaton Schroeder.

[11][12] On September 30, 1963, Nation filed to run for reelection, placed first in the primary, and won in the general election.

[4] During the general election campaign he spent $936 against Don Erickson's, who was endorsed by the Cheyenne Central Labor council despite being a Republican, $988.42.

[30][31] In 1974, Nation rejected an attempt by the American Nazi Party to establish a national headquarters in Cheyenne and called for other residents of Cheyenne to write to the American Nazi Party to express their views on the proposal.

[32] In 1973, the Model Cities Program in Cheyenne had charges of discrimination filed against it by the Cheyenne Local Development Corporation due to its budget being decreased and had been investigated by the United States Department of Housing and Urban Development.

[36] On March 9, 1967, Governor Stanley K. Hathaway appointed Bill Nation as one of nine members of the Wyoming Recreation Committee.