The show's byline was, "Emmy-winning host Bill Nye brings experts and famous guests to his lab for a talk show exploring scientific issues that touch our lives",[2] with the series' focus placed on science and its relationship with politics, pop culture, and society.

As such, some episodes have Nye discuss topics that would be considered inappropriate to mention to minors.

These include fashion model Karlie Kloss, science YouTuber and educator Derek Muller, comedian Nazeem Hussain, comedian and writer Joanna Hausmann, and the TV host and producer Emily Calandrelli.

Reception to the series has been mixed, with the first season being reviewed more positively by critics than audiences.

[7] It explores topics such as climate change, alternative medicine, and video games from a scientific point of view, while also refuting myths and anti-scientific claims.

On June 15, 2017, Nye announced on his Facebook page that the series had been renewed for a six-episode second season,[10] which premiered on December 29, 2017.

In particular, Rachel Bloom's performance in episode 9 has been described as "strange", "out of place",[9] and a "painful couple of minutes".

[15] Conversely, NPR's Fresh Air said the show is "fun to watch," working well with Nye's "consistent reliance on scientific and provable facts.

"[16] Vox praised Nye's unapologetic talking style, though worried this may alienate some viewers.