In 2000, with incumbent State Representative Cheryl Winkler unable to run again due to term limits, Seitz was nominated to succeed her.

When Senator Patty Clancy announced that she would resign her seat midway through 2007, Seitz was mentioned as the front-runner for the appointment to replace her.

For the 129th General Assembly, Seitz ran for a leadership position, but lost President Pro Tempore to Keith Faber and Majority Leader to Jimmy Stewart.

While Niehaus stated that it was due to his failure to keep another member informed about changes to a bill, many have speculated it was a political repercussion for voting against the measure.

[9] In March 2016, Seitz introduced HB 296, which would require a monetary payment (bond) for vote centers aka polling centers/places to remain open after their usual closing time of 7:30pm.

He said in an interview about his decision to retire, "I'll be 70 years old by the end of my term and I don't want to be a blithering idiot like Joe Biden, so I think that's probably long enough.

"[17] On January 24, 2018, the website 3rd Rail Politics reported Republican legislators' alleged sexist and demeaning comments toward women at a roast for outgoing Ohio House Speaker Cliff Rosenberger's chief of staff Mike Dittoe.

[18] Held at the Athletic Club of Columbus just down the street from the Capital Building, the event was attended by legislators, lobbyists and campaign contributors.

Former Senator Cliff Hite, who as first reported by 3rd Rail was drummed out of office for disturbing allegations of harassing a female statehouse staffer, could have Marvin Gaye's "Let's Get It on," Seitz joked.

[19] These remarks took place the same week House members received sexual harassment training mandated as a result of recent local and national scandals.

[21] Soon after, an anonymous woman filed a complaint, stating that Seitz's remarks worsened an already hostile working environment in the Statehouse.

Republican Attorney General Mike Dewine paid $12,000 to Taft Stettinius & Hollister to conduct an internal investigation.

[23] Rep. Michele Lepore-Hagan said, "...interviewing only two of the more than 100 people who attended the event where Rep. Seitz degraded women, and then burying the report makes it clear that the leadership of the House and AG DeWine wanted to whitewash this particular incident".

[24] State Reps. Teresa Fedor (D-Toledo) and Nickie J. Antonio (D-Lakewood) asked Ohio Attorney General (AG) Mike DeWine to hire an objective third party to reopen the harassment investigation of Rep. Bill Seitz (R-Cincinnati).