Skarsgård has also appeared in the comedy Simple Simon (2010), the drama Nine Days (2020), and the action films The Divergent Series: Allegiant (2016), Atomic Blonde (2017), and John Wick: Chapter 4 (2023).

In April 2014, Skarsgård featured on the cover of Hero – a bi-annual men's fashion and culture magazine, shot by Hedi Slimane.

[7] Skarsgård played Matthew in the science fiction thriller The Divergent Series: Allegiant (2016), his first major American film.

[8] He played horror villain Pennywise the Dancing Clown in the 2017 film It and reprised the role in the 2019 sequel, directed by Andy Muschietti.

[9] Speaking about what led him to casting Skarsgård, Muschietti said: "One second he can act all cute, and then the next, there's something ancestral and dark that just appears.

His ability to transform is mind-blowing to me.”[10] Skarsgård was a series regular on 2018's Castle Rock, as a young man with an unusual legal problem.

[13] Skarsgård played the lead villain role of Marquis de Gramont in John Wick: Chapter 4 (2023).