He pitched his entire career in the American League with the Cleveland Indians, Washington Senators, New York Yankees and Boston Red Sox.

Bill was born and raised in Middle Amana, Iowa, a community of German pietists who until 1932 practiced a form of communitarian living.

[3] In his first game against the Boston Red Sox, he pitched five innings and earned a win in the six-inning affair which was shortened due to rain.

[5][6] At the start of the 1946 season, Zuber pitched three games and had an ERA of over 12 before he was purchased by the Boston Red Sox on June 18.

[5] Zuber appeared in game four of the 1946 World Series, pitching two innings and allowing one run in a 12–3 loss to the St. Louis Cardinals.