During the 1950s and 1960s, hit songs of his were recorded by Dick Farney, Lúcio Alves [pt], João Gilberto, Dolores Duran, Sílvio Caldas, Nora Ney, Jamelão, Elizeth Cardoso, Dóris Monteiro, Os Cariocas, Pery Ribeiro, Miltinho, Elis Regina, Miriam Batucada and Hebe Camargo.

His first major success was “Estatutos da Gafieira", sung by Inezita Barroso, recorded at RCA Victor studios in 1954.

[citation needed] In 2009, he accepted the invite of filmmaker Cesar Nero to participate in the production of "Desde o Princípio" with his own song, "Sinfonia Paulistana", about a messenger from the future who arrives in São Paulo to attempt to avert catastrophe.

The production included the participation of Antonio Abujamra, Maximira Figueiredo, José Mojica Marins, Mario Gomes, and Chico Anysio.

[citation needed] While keeping the works of this production with Nero and exchanging information, Blanco continued to dedicate himself to gospel music until he suffered a stroke in 2010, being hospitalized in Rio de Janeiro.

[3] In 2012, the municipal government of Rio de Janeiro paid tribute to him, giving him name to the Mergulhão Billy Blanco, a construction project at the Trevo das Palmeiras (also known as the Cebolão) in the Barra da Tijuca neighborhood.