After trying his hand at composing it, he was threatened with expulsion from Trinity College if he continued, and it was a decade before his first composition was re-issued as 'The Jazz Master'.
In the late 20s he recorded in London a single title, "Eskimo Shivers", on the Duo-Art player piano system for the Aeolian Company.
In 1926, Mayerl left the Savoy and opened his 'School of Syncopation' which specialised in teaching modern music techniques such as ragtime and stride piano.
In December 1926, he appeared with Gwen Farrar (1899–1944) in a short film—made in the Lee de Forest Phonofilm sound-on-film process—in which they sang Mayerl's song "I've Got a Sweetie on the Radio".
In November 1927, his piano styles accompanied the Hamilton Sisters and Fordyce, American Vaudeville vocal harmonizers who first recorded in England.
Mayerl stepped in as bandleader for the Grosvenor House Hotel in May 1941, when Sydney Lipton was called up to serve with the Royal Corps of Signals.
He was cremated at Golders Green Crematorium in north London on 31 March 1959 and his ashes were placed in the Cedar Lawn Rose Bed.