In June 2013, he signed an exclusive contract with Men.com for six months, for whom he made his debut appearance in Boy Ranch Part 1 in July 2013.
[10] He became a board member for the Adult Performance Artists Guild in April 2018 but resigned later that month, claiming that the organization did not protect pornographic film actors, specifically those who were HIV-positive.
[2] Garridan P. Faxton of Fleshbot called Santoro "the hardest-working man in skin-business" in 2015 for his consistent appearances in new pornographic films.
[24] The post led to social media backlash against Santoro, who claimed in response to it that he had "lashed out full of emotional stress" due to the killing of his friend during looting in Philadelphia.
[25] Social media users then circulated other posts by Santoro, one in which he claimed that he had not experienced gay bashing from any "white, redneck Trump supporter" but had from "African American men who live in Shaw in DC", and another in which he responded to a restaurant's pro-Black Lives Matter tweet about being able to replace their property if it was destroyed during protests by tweeting that "the blacks will just breed more hatred towards them".
[27] He then created a new joint Twitter account with his husband, gay pornographic actor Gage, who posted photos of Santoro sitting in a hospital bed and claimed that he had attempted suicide over the backlash.
[30] In December 2020, Samantha Hutchinson and Stephen Brook of The Sydney Morning Herald wrote that Santoro and his husband "had gained international notoriety due to racist social comments they blamed on a meth addiction".