It was established in 1946 with faculty from Qingdao Medical College who moved to Binzhou.

In July 2001, a new campus in Yantai City, Shandong Province was started to establish.

In June 2003, the school was granted the right to confer a master's degree, and in 2004 it enrolled the first master's students in three majors: human anatomy, histology and embryology; internal medicine; oral clinical medicine.

In May 2013, it was selected as the first batch of pilot universities for the reform of the postgraduate training model for the master's degree in clinical medicine.

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